Altered proteasome function in right ventricular hypertrophy
نویسندگان
چکیده
منابع مشابه
Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure.
Alterations in the ubiquitin-proteasome system (UPS) have been described in left ventricular hypertrophy and failure, although results have been inconsistent. The role of the UPS in right ventricular (RV) hypertrophy (RVH) and RV failure (RVF) is unknown. Given the greater percent increase in RV mass associated with RV afterload stress, as present in many congenital heart lesions, we hypothesiz...
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The electrocardiograms of 22 cases showing isolated right ventricular hypertrophy at autopsy were examined for changes suggestive of right ventricular hypertrophy. Only 5 of 22 cases fulfilled at least one of the criteria of Sokolow and Lyon and only three could be diagnosed as having right ventricular hypertrophy by the criteria of Myers, Klein and Stofer. Factors contributing to the developme...
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Severe left ventricular volume overloading causes myocardial and cellular contractile dysfunction. Whether this is also true for severe right ventricular volume overloading was unknown. We therefore created severe tricuspid regurgitation percutaneously in seven dogs and then observed them for 3.5-4.0 yr. All five surviving operated dogs had severe tricuspid regurgitation and right heart failure...
متن کاملPolycythemia and Right Ventricular Hypertrophy.
• The chronic hypoxia of high altitude produces an elevated pulmonary arterial pressure" resulting in right ventricular hypertrophy.' Cournand has proposed that the pulmonary hypertension and subsequent right ventricular hypertrophy found in patients with chronic pulmonary disease are associated with polycythemia, hypervolemia, and increased cardiac output secondary to the hypoxemia present in ...
متن کاملEditorial note on right ventricular hypertrophy.
It has long been clear to me, and no doubt to many others, that extreme right axis deviation (large SI and RIII with insignificant RI and SIII) is common in many forms of pulmonary stenosis and other congenital heart diseases, much rarer in mitral stenosis (where a common finding is a small R in lead I and a larger R in leads II and III, the rRR type), and quite unusual in chronic pulmonary dis...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2019
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvz103